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  • Title: Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system.
    Author: Ueda K, Saeki T, Hirai M, Tanigawara Y, Tanaka K, Okamura M, Yasuhara M, Hori R, Inui K, Komano T.
    Journal: Jpn J Physiol; 1994; 44 Suppl 2():S67-71. PubMed ID: 7538609.
    Abstract:
    To analyze the mechanism of drug transport, mechanism of inhibitors, and physiological substrates of human P-glycoprotein, we established a transepithelial transport system by introducing MDR1 cDNA into LLC-PK1, a pig kidney epithelial cell line. P-glycoprotein functions as a steroid transporter as well as a drug transporter as physiological functions. P-glycoprotein also transports MDR modulators such as cyclosporin A, FK506, and calcium channel blockers.
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