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  • Title: Synthesis of pyrryl aryl sulfones targeted at the HIV-1 reverse transcriptase.
    Author: Artico M, Silvestri R, Stefancich G, Massa S, Pagnozzi E, Musu D, Scintu F, Pinna E, Tinti E, La Colla P.
    Journal: Arch Pharm (Weinheim); 1995 Mar; 328(3):223-9. PubMed ID: 7539250.
    Abstract:
    Various aryl 1-pyrryl sulfones were synthesized and tested as inhibitors of HIV-1. 2-Nitrophenyl-2-ethoxycarbonyl-1-pyrryl sulfone, the most active among test derivatives, was selected as lead compound of the aryl pyrryl sulfone series. The in vitro anti-HIV-1 activity and cytotoxicity of 41 compounds is reported. Some structure-activity relationships are discussed also in comparison with the known NPPS (2-nitrophenyl phenyl sulfone).
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