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  • Title: Osteoporosis in severe congenital neutropenia treated with granulocyte colony-stimulating factor.
    Author: Bishop NJ, Williams DM, Compston JC, Stirling DM, Prentice A.
    Journal: Br J Haematol; 1995 Apr; 89(4):927-8. PubMed ID: 7539627.
    Abstract:
    Recombinant human granulocyte colony-stimulating factor (G-CSF) has substantially improved life expectancy for children with severe congenital neutropenia (SCN). Severe osteoporosis, reported in this population, may relate to the disease process, or be a therapeutic side-effect. This report details bone loss, quantitated absorptiometrically and histomorphometrically, in a child with SCN and vertebral collapse, and the positive response to anabolic steroid and bisphosphonate therapy.
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