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  • Title: [RAEB in T with monosomy 7 after treatment of severe aplastic anemia with long term G-CSF].
    Author: Kaito K, Otsubo H, Ogasawara Y, Sekita T, Saeki A, Nishiwaki K, Masuoka H, Shimada T, Kobayashi M, Sakai O.
    Journal: Rinsho Ketsueki; 1995 Apr; 36(4):365-70. PubMed ID: 7540227.
    Abstract:
    A 19-year-old male who suffered from severe aplastic anemia had been treated with granulocyte colony stimulating factor (G-CSF) from September 1991. Marked increase of hematopoietic cells in his bone marrow was observed, and maintenance administration of G-CSF was continued. 15 months later, myeloblasts with nuclear abnormality increased, and 22 months later, myeloblasts with chromosomal abnormality presenting 46, XY, -7, +21 exceeded 20%, and aplastic anemia seemed to be transformed into refractory anemia with excess of blasts in transformation (RAEB in T). The usefulness of G-CSF in the treatment of aplastic anemia is now established, but there are some reports questioning the effect of long-term administration, especially transformation to MDS with monosomy 7. Leukemic transformation from aplastic anemia is very complex, but in some cases, long term administration of G-CSF may affect the natural course and may lead to the earlier development of leukemia.
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