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  • Title: The effect of colchicine and vinblastine on bleomycin-induced lung fibrosis in rats.
    Author: Ledwozyw A.
    Journal: Acta Physiol Hung; 1994; 82(4):383-9. PubMed ID: 7540348.
    Abstract:
    The effect of colchicine and vinblastine on collagenase, lysyl oxidase and prolyl hydroxylase activities as well as on collagen cross-linking and types of this protein in bleomycin induced lung fibrosis in rats was investigated. Both colchicine and vinblastine diminish bleomycin-induced changes in the above-mentioned enzyme activities as well as collagen cross-linking and normalize type I/type III collagen ratio.
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