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  • Title: Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash.
    Author: McMullin MF, Finch MB.
    Journal: Clin Rheumatol; 1995 Mar; 14(2):204-8. PubMed ID: 7540527.
    Abstract:
    A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.
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