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Title: Lipopolysaccharide recovery restores susceptibility levels towards beta-lactams in Serratia marcescens. Author: Palomar J, Puig M, Montilla R, Lorén JG, Viñas M. Journal: Microbios; 1995; 82(330):21-6. PubMed ID: 7540714. Abstract: O-side chain-defective spontaneous mutants of Serratia marcescens, selected by phage resistance, showed lower MICs against various beta-lactams than did their parental strains. The recovery of their ability to produce O-antigen restored the original MIC values, as well as phage susceptibility. The permeability coefficients of wild-type, O- mutants, and revertants, demonstrated that O-antigen modifies the permeability of antibiotics in S. marcescens.[Abstract] [Full Text] [Related] [New Search]