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  • Title: C-myc amplification, double minutes and homogenous staining regions in a case of AML.
    Author: Fegan CD, White D, Sweeney M.
    Journal: Br J Haematol; 1995 Jun; 90(2):486-8. PubMed ID: 7540858.
    Abstract:
    c-myc amplification is usually associated with lymphoid malignancies and Burkitt's lymphoma in particular. We present a case of AML with c-myc amplification which was associated with homogenous staining regions (hsr) and double minutes (dmin). The administration of GCSF following induction chemotherapy resulted in a marked increase in blast numbers. The GCSF was stopped and further courses of chemotherapy given, which resulted in complete remission. The patient relapsed 7 months after diagnosis and failed to go into a second remission with reinduction therapy. We conclude that c-myc amplification is a rare event in AML, but may be associated with chemotherapy resistance and a poor prognosis, are as dmins and hsr. Growth factors should be used with caution in these patients.
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