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  • Title: Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons.
    Author: Sretavan DW, Puré E, Siegel MW, Reichardt LF.
    Journal: Science; 1995 Jul 07; 269(5220):98-101. PubMed ID: 7541558.
    Abstract:
    Mouse retinal ganglion cell axons growing from the eye encounter embryonic neurons at the future site of the optic chiasm. After in vivo ablation of these chiasm neurons with a monoclonal antibody and complement, retinal axons did not cross the midline and stalled at approximately the entry site into the chiasm region. Thus, in the mouse, the presence of early-generated neurons that reside at the site of the future chiasm is required for formation of the optic chiasm by retinal ganglion cell axons.
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