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  • Title: Physiologic variations of serum testosterone within the normal range do not affect serum prostate-specific antigen.
    Author: Monath JR, McCullough DL, Hart LJ, Jarow JP.
    Journal: Urology; 1995 Jul; 46(1):58-61. PubMed ID: 7541587.
    Abstract:
    OBJECTIVES: To determine the relationship between endogenous total serum testosterone levels and serum prostate-specific antigen (PSA) concentrations. If a correlation exists between these two parameters, then use of testosterone-specific reference ranges may enhance the utility of PSA as a marker for prostate cancer. METHODS: Data were obtained from 150 men without previous history of prostate cancer. PSA was measured by the Abbott IMX microparticle enzyme immunoassay and total testosterone determined by the Coat-A-Count radioimmunoassay. RESULTS: No correlation was found between testosterone and PSA, even when corrected for age and weight. CONCLUSIONS: The data suggest that determination of the total serum testosterone level does not improve the sensitivity or specificity of PSA as a tumor marker.
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