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  • Title: Effects of interleukin-4 or stem cell factor on mast cell mediator release and cytokine gene expression.
    Author: Coleman JW, Buckley MG, Taylor AM, Banks EM, Williams CM, Holliday MR, Thompson J.
    Journal: Int Arch Allergy Immunol; 1995; 107(1-3):154-5. PubMed ID: 7542063.
    Abstract:
    We have investigated the capacity of interleukin (IL)-4 or stem cell factor (SCF) to induce direct mediator release from rodent peritoneal mast cells, and also to induce or regulate cytokine gene expression in the human HMC-1 mast cell line. SCF, but not IL-4, induced low levels of serotonin release from mouse or rat peritoneal mast cells; rat mast cells acquired enhanced responsiveness to SCF during culture. IL-4, but not SCF, enhanced ionomycin-induced transcription and secretion of several genes, including the cytokines IL-3, IL-4, granulocyte/macrophage-colony-stimulating factor, IL-8 and the receptor for IL-6 in the human HMC-1 mast cell line.
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