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  • Title: Interleukin-13 regulates the phenotype and function of human monocytes.
    Author: Viale G, Vercelli D.
    Journal: Int Arch Allergy Immunol; 1995; 107(1-3):176-8. PubMed ID: 7542068.
    Abstract:
    The monocyte glycosylphosphatidylinositol (GPI)-linked protein CD14 serves as the receptor for lipopolysaccharide (LPS), and regulates monocyte-lymphocyte interactions. We investigated whether CD14 expression is regulated by interleukin (IL)-13, a member of the chromosome 5 cytokine family. IL-13 inhibited CD14 expression on human monocytes. CD14 down-regulation resulted in the inhibition of LPS-induced release of tumor necrosis factor alpha, and involved neither shedding nor activation of endogenous GPI-anchor-cleaving enzymes. The CD14/actin RNA ratio was decreased 7-fold in IL-13-treated monocytes. Our results suggest that IL-13 down-regulates CD14 by suppressing CD14 RNA expression. Down-regulation of CD14, the LPS receptor, may play a major role in the anti-inflammatory effects of IL-13.
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