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  • Title: Nitric oxide synthase inhibition and food intake: effects on motivation to eat and in female mice.
    Author: Morley JE, Farr SA, Suarez MD, Flood JF.
    Journal: Pharmacol Biochem Behav; 1995 Mar; 50(3):369-73. PubMed ID: 7542389.
    Abstract:
    Recent studies have demonstrated that nitric oxide may play an important role in the regulation of food intake. The studies reported here extend these findings by demonstrating that NG-nitro-arginine-methylester, N-Arg(ME), a nitric oxide synthase inhibitor, decreased intake of a highly palatable substance (i.e., milk), though at a higher dose than necessary for decreasing consumption of food pellets. N-Arg(ME) failed to inhibit lever press for milk reward in nonprefed mice, but decreased lever pressing in prefed mice. N-Arg(ME) decreased food intake in female mice, being most potent in proestrus. These studies suggest that nitric oxide synthase inhibition decreases food intake without inducing aversion or illness.
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