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  • Title: Amylase, lipase, pancreatic isoamylase, and phospholipase A in diagnosis of acute pancreatitis.
    Author: Clavé P, Guillaumes S, Blanco I, Nabau N, Mercé J, Farré A, Marruecos L, Lluís F.
    Journal: Clin Chem; 1995 Aug; 41(8 Pt 1):1129-34. PubMed ID: 7543034.
    Abstract:
    To determine the utility of serum amylase (AMY), lipase (Lp), pancreatic isoamylase (isoA), phospholipase A (PLA), and urine AMY in the diagnosis of acute pancreatitis, samples of serum and urine were obtained on admission and every day thereafter for 5 days from 384 patients with acute abdominal pain. Diagnostic accuracy, determined as the area under the receiver operating characteristic curve, was > 0.975 for serum AMY, Lp, isoA, and urine AMY. For each of these enzymes, a threshold value (twice to sixfold the upper limit of the reference values) offering diagnostic efficiency > 95% could be determined. In contrast, accuracy and efficiency of serum PLA were low. The profiles of these enzymes in acute pancreatitis decreased in a parallel fashion over 5 days except for PLA. We conclude that diagnostic utilities are similar for serum AMY, Lp, isoA, and urine AMY for acute pancreatitis, provided that an appropriate threshold is established.
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