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  • Title: [Single channel analysis of aconitine blockade of calcium channels in rat myocardiocytes].
    Author: Chen L, Ma C, Cai BC, Lu YM, Wu H.
    Journal: Yao Xue Xue Bao; 1995; 30(3):168-71. PubMed ID: 7543723.
    Abstract:
    Ventricular myocardiocytes from neonatal Wistar rats were isolated and cultured. Aconitine, Ca2+ channel blocker verapamil or Ca2+ channel activator BAY K8644 were added to the bath solution separately. Using the cell-attached configuration of the patch clamp technique, the single channel activities of L type Ca2+ channel were recorded before and after addition of all three drugs. The results showed the blocking effect of aconitine (50 micrograms.ml-1) on L type Ca2+ channels. Its mechanism may be relevant to the decrease in both open state probability and the mean open time of Ca2+ channel. The difference was statistically significant compared with control group (P < 0.01). The amplitude of Ba2+ currents, which flow through open L type Ca2+ channel was unchanged.
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