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  • Title: Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats.
    Author: Maggio R, Fumagalli F, Donati E, Barbier P, Racagni G, Corsini GU, Riva M.
    Journal: Brain Res; 1995 May 08; 679(1):184-7. PubMed ID: 7544223.
    Abstract:
    We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.
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