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  • Title: [Expression of intercellular adhesion molecule-1 and vascular adhesion molecule-1 in kidney of patients with lupus nephritis and membranoproliferative glomerulonephritis].
    Author: Chen X, Xu Q, Tang L.
    Journal: Zhonghua Bing Li Xue Za Zhi; 1995 Jun; 24(3):149-51. PubMed ID: 7544695.
    Abstract:
    Immunohistochemical and computer-imaging analysis techniques were used to detect the expression of intercellular adhesion molecule 1 (ICAM-1) and vascular adhesion molecule 1 (VCAM-1) in the kidney of 25 patients with lupus nephritis (LN) type IV and in 15 patients with membranoproliferative glomerulonephritis (MPGN) type I. Results showed that ICAM-1 and VCAM-1 expressions were increased significantly in the kidneys of patients with MPGN and LN and that ICAM-1 in the glomeruli of LN patients correlated well with glomerular endothelial cell proliferation. ICAM-1 and VCAM-1 may well take a role in the pathogenesis of LN and MPGN.
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