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  • Title: Induction of cytochrome P-450 by 5-methoxypsoralen in the yeast Saccharomyces cerevisiae.
    Author: Del Carratore R, Morichetti E, Bronzetti G, Galeotti C.
    Journal: J Environ Pathol Toxicol Oncol; 1994; 13(4):227-30. PubMed ID: 7544830.
    Abstract:
    Yeast cells (D7 strain) incubated in the presence of 5-methoxypsoralen (5-MOP) increase the activity of the monooxygenase system cytochrome P-450 dependent (cytochrome P-450 level and 7-ethoxycoumarin-O-diethylase activity). Northern analysis of cytochrome P-450 specific RNA shows that 5-MOP treatments induce an increase in mRNA. The induction of cytochrome P-450 appears to occur at the transcriptional level. The capacity of 5-MOP to induce the cytochrome P-450 system in eukaryotic cells, in which it is known to be involved in the metabolism of the psoralen, may decrease the availability of the compound for photo-induced genotoxic reactions, which may explain the good tolerance in patients.
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