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  • Title: Effect of indomethacin on aldosterone secretion in chronic sodium depletion.
    Author: Spät A, Fejes Tóth G.
    Journal: Acta Physiol Acad Sci Hung; 1978; 52(1):87-91. PubMed ID: 754490.
    Abstract:
    Aldosterone secretion rate was determined in sodium repleted and sodium depleted rats 3 to 5 hours hypophysectomy. Sodium depletion was performed by keeping the rats on wheat for six days. This diet resulted in a significant increase in aldosterone secretion rate. Hypersecretion of aldosterone could be observed also after administration of indomethacin, an inhibitor of prostaglandin synthesis.
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