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Title: The effect of beta-aminopropionitrile on bleomycin-induced lung injury in rats. Author: Ledwozyw A. Journal: Acta Physiol Hung; 1995; 83(1):91-9. PubMed ID: 7544946. Abstract: The effect of beta-aminopropionitrile on collagen cross-links, lysyl oxidase and prolyl hydroxylase and particular collagen type content in rat lungs after bleomycin treatment was investigated. It was stated, that beta-aminopropionitrile significantly diminishes elevated dihydroxylysinonorleucine to hydroxylysinonorleucine ratio, prevented increase of lysyl oxidase activity and increase in type I collagen content in the lungs. It is suggested, that beta-aminopropionitrile may be useful in the treatment of lung fibrosis.[Abstract] [Full Text] [Related] [New Search]