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  • Title: Neurodevelopmental outcome in very low birthweight infants with necrotizing enterocolitis requiring surgery.
    Author: Tobiansky R, Lui K, Roberts S, Veddovi M.
    Journal: J Paediatr Child Health; 1995 Jun; 31(3):233-6. PubMed ID: 7545411.
    Abstract:
    OBJECTIVE: To assess the effect of necrotizing enterocolitis (NEC) on neurodevelopmental outcome. METHODOLOGY: Neurodevelopmental outcome of 20 very low birthweight (VLBW) infants who developed NEC requiring surgery was compared with 40 matched infants controlled for gestation, birthweight, and year of admission. Twenty-nine VLBW infants who developed NEC and did not require surgery were also compared. RESULTS: Infants with NEC needing surgery were of 26 +/- 2 weeks gestation and weighted 892 +/- 192 g at birth. Infants with NEC managed medically were of higher gestation (27 +/- 2 weeks) but similar birthweights. More infants with NEC requiring surgery required inotropic support. At follow up, NEC surgery infants had a significantly higher incidence of developmental morbidity. 11 of 20 compared with 11 of 40 matched controls (Fisher's exact test P = 0.0493), and six of 29 infants with NEC managed medically (Fisher's exact test P = 0.0174). CONCLUSIONS: These findings stress the importance for close follow up for neurodevelopmental sequelae in VLBW infants who have had NEC requiring surgery.
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