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  • Title: Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis.
    Author: Sundvall M, Jirholt J, Yang HT, Jansson L, Engström A, Pettersson U, Holmdahl R.
    Journal: Nat Genet; 1995 Jul; 10(3):313-7. PubMed ID: 7545492.
    Abstract:
    B10.RIII mice develop chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with the myelin basic protein (MBP) peptide 89-101. The disease is associated with the major histocompatibility complex (MHC) (eae1). We have now investigated the importance of non-MHC regions for the EAE susceptibility in a cross between RIIIS/J and B10.RIII mice which share the MHC region but differ in disease susceptibility. Linkage analysis using microsatellite markers spanning the genome identified a region (eae2) on chromosome 15 which showed linkage to disease (P = 0.0002). Our data also suggest linkage to a second region (eae3) on chromosome 3 (P = 0.0024), and provide evidence for locus interactions between eae2 and eae3. These results provide clues to the genetic basis of multiple sclerosis.
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