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  • Title: Nucleotide sequence of the HIV-2 EHO genome, a divergent HIV-2 isolate.
    Author: Galabru J, Rey-Cuillé MA, Hovanessian AG.
    Journal: AIDS Res Hum Retroviruses; 1995 Jul; 11(7):873-4. PubMed ID: 7546916.
    Abstract:
    The HIV-2 EHO isolate from Cote d'Ivoire has been characterized as a highly cytopathic HIV-2 strain, which can be differentiated from other isolates by the smaller size of its external envelope glycoprotein. The entire nucleotide sequence (10,352 bp) of the HIV-2 EHO genome is filed in the EMBL/Genbank Data Libraries under Accession No. U27200. Despite its high degree of variability, the genetic organization of HIV-2 EHO was found to be similar to other HIV-2 and simian immunodeficiency virus (SIV) isolates: it contains the long terminal repeats (LTR) and the 5' and 3' ends, the structural genes, and the genes encoding proteins which transactivate the HIV genome and those for accessory proteins. McClure et al. have demonstrated that HIV-2 EHO can infect Macaca nemestrina, resulting in progression to an AIDS-like disease in 50% of the macaques challenged. The researchers have more recently reported that passage of HIV-2 EHO in such macaques increases its virulence, resulting in a persistent infection and progression to AIDS in all inoculated animals. Given these observations, its unique biological and genetic properties, and the fact that it was isolated from a full-blown AIDS patient, it is plausible to suggest that HIV-2 EHO represents a distinct subtype of HIV-2 with an increased potential to trigger a rapid disease progression toward AIDS. The nucleotide sequence reported in this paper should be helpful in determining the prevalence of HIV-2 EHO in HIV-2 seropositive patients, and in evaluating its role in the evolution of AIDS.
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