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  • Title: Plasma, cytosolic and membrane magnesium content in renal insufficiency.
    Author: Kisters K, Spieker C, Tepel M, Wenserski F, Zidek W.
    Journal: Magnes Res; 1995 Jun; 8(2):169-74. PubMed ID: 7547178.
    Abstract:
    Plasma magnesium, cytosolic (lymphocytic) and membrane (erythrocytic) magnesium concentrations were determined in 15 controls with normal renal function compared to 12 patients with renal insufficiency (chronic glomerulonephritis, serum creatinine 2.5 +/- 0.8 mg/dl, mean +/- SD). Plasma magnesium concentrations were determined by atomic absorption spectroscopy (AAS), cytosolic free magnesium with the fluorescent indicator Mag-Fura-2, and membrane magnesium by AAS, referred to membrane protein content which was determined according to Bradford's method. Plasma magnesium was 0.91 +/- 0.08 mmol/litre in controls versus 0.95 +/- 0.09 mmol/litre in renal-insufficient patients. Cytosolic free magnesium content was 2.38 +/- 0.75 mmol/litre in controls and 2.61 +/- 0.35 mmol/litre in the renal-insufficient group. In the renal-insufficient group membrane magnesium concentrations were found to be significantly increased as compared to the control group (2.85 +/- 0.62 vs 0.53 +/- 0.22 mmol/g membrane protein, mean +/- SD, P < 0.05). The results show that cell membranes may be of special importance in renal insufficiency in avoiding magnesium overload of the cell and in keeping free cytosolic magnesium stores stable.
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