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  • Title: [Liberation of inorganic phosphates in the coronary sinus as an indicator of human myocardial ischemia].
    Author: Gavazzi A, Mussini A, Pavesi F, Marinoni GP, Bramucci E, De Servi S, Valsecchi O, Specchia G.
    Journal: Boll Soc Ital Biol Sper; 1978 Nov 30; 54(22):2271-6. PubMed ID: 754726.
    Abstract:
    The effects of atrial pacing (A.P.) on the myocardial balance of inorganic phosphate (Pi) were studied in 11 patients with coronary atherosclerosis and pacing-induced angina (Group C) and in 5 normal subjects (Group N). During A.P. in group C 64% of patients had myocardial loss of Pi, statistically significant (p less than 0,025) always with concomitant reduced myocardial extraction or production of lactate, but only 70% of patients with reduced myocardial extraction or production of lactate had myocardial loss of Pi. In only 1 p. of group N myocardial loss of Pi with normal lactate extraction was observed. These data show that during pacing-induced ischemia there is a negative myocardial balance of Pi, that can be used as a metabolic indicator of ischemia, but less reliable than lactate reduced extraction or production.
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