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  • Title: Expression of stereotyped behaviour requires stimulation of nigral D1 dopamine receptors.
    Author: Lee CY, Double KL, Crocker AD.
    Journal: Brain Res; 1995 May 29; 681(1-2):205-8. PubMed ID: 7552282.
    Abstract:
    Dopamine receptors in the pars reticulata of the substantia nigra were inactivated following bilateral injections of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Loss of D1, but not D2, receptors was associated with a significant decrease in the incidence of stereotyped head-down sniffing elicited by the mixed D1/D2 receptor agonist, apomorphine. The results support the hypothesis that D1 receptors in the substantia nigra are necessary for the expression of dopamine mediated stereotyped behaviour.
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