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  • Title: Intravenous immunoglobulin infusion in multifocal demyelinating motor neuropathy: a case report.
    Author: Lin YY, Tsai CP, Ting YC, Lin KP, Liao KK, Kao KP, Wang SJ.
    Journal: Zhonghua Yi Xue Za Zhi (Taipei); 1995 Jul; 56(1):66-9. PubMed ID: 7553414.
    Abstract:
    The following report is a case of multifocal demyelinating motor neuropathy (MMN) presenting as a gradual development of asymmetric motor weakness without sensory involvement. Electrophysiological studies showed mainly a conduction block with normal or slightly slow nerve conduction velocity. Cerebrospinal fluid (CSF) protein and serum protein electrophoresis were normal, but serum IgM anti-GM1 ganglioside antibody was elevated. The patient had a poor response to steroid, plasmapheresis and chemotherapy with cyclophosphamide, but significant improvement was noted after intravenous immunoglobulin (IVIG) infusion. MMN is a potentially treatable condition which clinically mimics a motor neuron disease; if treatment with steroid, plasmapheresis and cyclophosphamide have failed, IVIG may be effective.
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