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  • Title: Reevaluations of disk diffusion susceptibility testing interpretive criteria for lomefloxacin and norfloxacin using fluoroquinolone-resistant isolates.
    Author: Cormican MG, Jones RN.
    Journal: Diagn Microbiol Infect Dis; 1995 Apr; 21(4):227-30. PubMed ID: 7554807.
    Abstract:
    The current National Committee for Clinical Laboratory Standards interpretive criteria for disk diffusion susceptibility testing of lomefloxacin and norfloxacin were reevaluated using a test panel of 298 bacteria (200 with ciprofloxacin minimum inhibitory concentrations (MICs) at > or = 4 micrograms/ml). MICs were correlated with the diameter of zones of inhibition by regression statistics and error-rate bounding methods. Modifications of the interpretive criteria for lomefloxacin disk susceptibility testing are proposed as follows: susceptible at > or = 20 mm and resistant at < or = 16 mm, a 2-mm decrease of existing break-point zones. These criteria result in an absolute interpretive agreement of 95.3% with a very major (false susceptible) error rate of only 0.7%. The currently used criteria for norfloxacin (susceptible at > or = 16 mm and resistant at < or = 13 mm) were validated, and these break-points had an absolute interpretive correlation between methods of 91.9%. The change proposed for lomefloxacin disk interpretations would minimize minor and major errors most often reported for Staphylococcus saprophyticus isolates.
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