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  • Title: Carbamazepine treatment of cocaine dependence: a placebo-controlled trial.
    Author: Kranzler HR, Bauer LO, Hersh D, Klinghoffer V.
    Journal: Drug Alcohol Depend; 1995 Jun; 38(3):203-11. PubMed ID: 7555620.
    Abstract:
    Cocaine-induced kindling, which has been hypothesized to underlie cocaine-induced craving, is reversed by carbamazepine treatment. Though preliminary studies showed carbamazepine to be useful for relapse prevention in cocaine-dependent subjects, more recent studies have failed to replicate those findings. We conducted a randomized, double-blind, placebo-controlled trial of carbamazepine 600 mg/day in 40 cocaine-dependent males. During active treatment there were no significant effects of carbamazepine on cocaine use, alcohol consumption, anxiety or depressive symptoms. At three months post-treatment carbamazepine-treated subjects reported fewer drinking days. We conclude that carbamazepine at this dose level is probably not efficacious for treatment of cocaine dependence.
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