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  • Title: Craniovertebral junction anomalies in inherited disorders: part of the syndrome or caused by the disorder?
    Author: Crockard HA, Stevens JM.
    Journal: Eur J Pediatr; 1995 Jul; 154(7):504-12. PubMed ID: 7556312.
    Abstract:
    Patterns of skeletal abnormality at the craniovertebral junction in the normal population and in syndromes such as Down, Morquio etc, are compared and the recent embryological data and comparative anatomy reviewed. The authors' view based on their own clinical and radiological experience is that the os odontoideum is the product of excessive movement at the time of ossification of the cartilaginous dens and is exactly analogous to the unfused Type II odontoid fracture. True hypoplasia of the odontoid peg is part of a wider segmentation defect associated with Klippel Feil, occipitalised atlas and/or basilar invagination; it is hardly ever associated with instability.
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