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  • Title: Prothymosin alpha mRNA levels vary with c-myc expression during tissue proliferation, viral infection and heat shock.
    Author: Vareli K, Frangou-Lazaridis M, Tsolas O.
    Journal: FEBS Lett; 1995 Sep 11; 371(3):337-40. PubMed ID: 7556624.
    Abstract:
    Expression of prothymosin alpha, an acidic nuclear protein implicated in cellular proliferation, has been reported to be regulated by c-myc in vitro. We have studied the correlation of expression levels between prothymosin alpha and c-myc, using three different in vivo systems, viz. normal ontogenic process of placental development, lytic viral infection and heat shock treatment. The two genes have been found to share a similar expression pattern, although prothymosin alpha mRNA remains always detectable, indicating the existence of yet another mechanism, in addition to c-myc, which regulates its expression in vivo.
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