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Title: Single dose ceftriaxone versus single dose cefuroxime plus metronidazole for preventing febrile morbidity and urinary tract infection in vaginal hysterectomy. Author: Brouwer WK, Hoogkamp Korstanje JA. Journal: Eur J Obstet Gynecol Reprod Biol; 1995 Aug; 61(2):143-6. PubMed ID: 7556835. Abstract: OBJECTIVE: To compare the prophylactic efficacy of 1 g ceftriaxone with 1.5 g cefuroxime + 0.5 g metronidazole for febrile morbidity and urinary tract infection in patients undergoing vaginal hysterectomy. STUDY DESIGN: A prospective, randomized, comparative, non-blinded study with at least 100 patients on each side. The two-sample t-test was used for testing equality of two means and the chi 2 test was used for pair differences. RESULTS: Single dose cefuroxime + metronidazole and ceftriaxone were equally effective in preventing febrile morbidity postoperatively. Additionally ceftriaxone was more effective in sterilizing pre-operatively existing bacteriuria.[Abstract] [Full Text] [Related] [New Search]