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  • Title: Synthesis and antimalarial activities of several fluorinated artemisinin derivatives.
    Author: Pu YM, Torok DS, Ziffer H, Pan XQ, Meshnick SR.
    Journal: J Med Chem; 1995 Sep 29; 38(20):4120-4. PubMed ID: 7562948.
    Abstract:
    The carbonyl groups in several artemisinin derivatives were converted into geminal difluorinated compounds on treatment with diethylaminosulfur trifluoride. A number of other mono- and polyfluorinated artemisinin derivatives were prepared. Their in vitro antimalarial activities were all equal to or greater than the nonfluorinated analogs or precursors.
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