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  • Title: [A benign clear cell tumor of the lung that grew gradually over five years].
    Author: Mishina T, Suzuki I, Fujino M, Watanabe N, Akita H, Narita Y, Kawakami Y.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1995 Jul; 33(7):765-70. PubMed ID: 7564005.
    Abstract:
    A 38-year-old man was found to have an abnormal shadow in his chest X-ray film during a general medical examination. A nodule with a homogeneous density and a clear margin was seen in the upper lobe of the right lung. Since this shadow gradually enlarged during a five-year follow-up period, he was admitted to our hospital. Chest contrast and dynamic CT scans and aortography showed characteristics of a benign tumor with somewhat rich vascularity. The doubling time of this tumor was about 430 days. Transbronchial brushing for cytologic study and a transbronchial biopsy showed no malignancy. However, the tumor was surgically resected because of its gradual growth over the five years. The resected tumor was histologically diagnosed as a benign clear cell tumor of the lung. This disease was first described by Leibow and Castleman in 1963, as a benign pulmonary tumor similar to metastatic renal cell carcinoma. This disease is extremely rare and only 61 cases have been reported: twenty cases, including the present case, in Japan and 41 in other countries.
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