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  • Title: [Significance of combined use of anticoagulants and antiplatelet agents in the early stage after prosthetic valve replacement].
    Author: Toyohira H, Nakamura K, Kariyazono H, Yamada K, Moriyama Y, Shimokawa S, Saigenji H, Taira A.
    Journal: Kyobu Geka; 1995 Aug; 48(9):749-55. PubMed ID: 7564036.
    Abstract:
    Patients who had undergone prosthetic valve replacement were treated with warfarin (anticoagulant) alone or in combination of ticlopidine (200 mg/day) or aspirin (81 mg/day) (anti-platelet agents). The study of blood coagulation factors and platelet aggregation were carried out with these cases. 1) The patients (n = 24) receiving warfarin for 21 days after prosthetic valve replacement revealed marked increases in PIVKA-II and vitamin K1-epoxide. The protein C activity was significantly lower than that before the operation. High levels of more than 5 ng/ml of TAT were found before operation and after warfarin administration for 21 days. 2) Warfarin did not affect platelet aggregation, whereas ticlopidine inhibited ADP-induced platelet aggregation and aspirin inhibited both collagen-induced and arachidonic acid-induced aggregation. In conclusion, combined use of anticoagulants and antiplatelet agents after prosthetic valve replacement will suppress not only the blood coagulation but also the platelet aggregation systems.
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