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  • Title: [Treatment of motor fluctuations in Parkinson's disease with subcutaneous injections of apomorphine].
    Author: Merello M, Leiguarda R.
    Journal: Medicina (B Aires); 1995; 55(1):5-10. PubMed ID: 7565037.
    Abstract:
    Sixteen patients with Parkinson's disease and severe motor fluctuations were treated with subcutaneous injections of apomorphine and followed up prospectively for a year. The use of the drug improved the number of daily "off" hours by 52%, while treatment efficacy remained constant for a year without the appearance of tolerance (ANOVA with repeated measurements:p = 0.0002). No severe adverse effect or any justifying treatment discontinuance were recorded. Apomorphine proved a safe and reliable drug for the treatment of motor fluctuations.
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