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  • Title: Prevention of remodeling of the heart after myocardial infarction.
    Author: Gorlin R.
    Journal: Mt Sinai J Med; 1995 Sep; 62(4):287-92. PubMed ID: 7565851.
    Abstract:
    Secondary prevention is critical following myocardial infarction. Infarct expansion leads to cardiomegaly, which may adversely affect prognosis. Infarct expansion seems to be associated with hypertension, anterior location, persistent (probably sudden) occlusion of the infarct artery, and poor collateralization. Prevention of cardiomegaly by angiotensin-converting-enzyme inhibitors, and possibly nitrates, seems to improve survival. Angiotensin-converting-enzyme inhibitors seem to delay the onset and the frequency of congestive failure and recurrent myocardial infarction.
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