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  • Title: [Possibility of using enriched glial and neuronal cell fractions to study transport of neurotransmitter amino acids in old age].
    Author: Aprikian GV, Shaginian VA, Gevorkian GA, Akhverdian ES, Melikian AM.
    Journal: Vopr Biokhim Mozga; 1978; 13():295-302. PubMed ID: 756645.
    Abstract:
    Calculated on a protein basis the yield of neuronal and glial cell-enriched fractions obtained from the brain of aged and adult rats was found to be equal. In aged animals the high affinity uptake of 14C-GABA by neuronal fractions is reduced by 27.34% while that of glial fractions by 11.87%. At 0 degrees both age groups studied the uptake of 14C-GABA is greatly inhibited--by 66% in neurones and 92% in glia. The conclusion is drawn that glial cells are changed much less with age than neurones and thus their role as modulators of neuronal function increases with age.
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