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  • Title: Central administration of cholecystokinin stimulates gastric pepsinogen secretion from anaesthetized rats.
    Author: Blandizzi C, Natale G, Carignani D, Colucci R, Lazzeri G, Del Tacca M.
    Journal: Neurosci Lett; 1995 Jun 23; 193(1):13-6. PubMed ID: 7566655.
    Abstract:
    Intracerebroventricular administration of CCK-8S was associated with a stimulation of gastric pepsinogen secretion from anaesthetized rats; similar effects were induced by CCK-8S given intravenously. The excitatory effect of intracerebroventricular CCK-8S was not modified by central injection of L-364,718 or L-365,260, whereas both these antagonists, given by intravenous route, prevented the pepsigogue action of parenteral CCK-8S. Intracerebroventricular or intravenous CCK-8S also increased basal acid secretion, this latter effect being prevented by parenteral L-365,260 but not L-364,718. It is suggested that centrally applied CCK-8S evokes pepsinogen secretion through the activation of peripheral CCK-A and CCK-B receptors.
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