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  • Title: Odor responses after complete desensitization of the cAMP-dependent pathway in turtle olfactory cells.
    Author: Kashiwayanagi M, Kurihara K.
    Journal: Neurosci Lett; 1995 Jun 23; 193(1):61-4. PubMed ID: 7566668.
    Abstract:
    The degree of contribution of the cAMP signal transduction pathway to odor responses was examined by recording current responses from isolated turtle olfactory cells under the whole-cell voltage clamp conditions. The cAMP signal transduction pathway was desensitized by dialyzing 1 mM cAMP and 0.5 mM IBMX from the patch pipette into the cells. Extracellular application of 3 mM cpt-cAMP, a membrane-permeable cAMP analogue elicited no response, indicating that the cAMP pathway was completely desensitized. Application of an odorant cocktail induced a large inward current under these conditions, suggesting that the cAMP-independent signal transduction contributes significantly to generation of odor responses in the turtle.
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