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  • Title: [Cellular and intracellular markers of lymphocyte activation in patients with infiltrative pulmonary tuberculosis].
    Author: Mishin VIu, Pavliuk AS, Bela MV, Koval'chuk LV.
    Journal: Probl Tuberk; 1995; (4):45-8. PubMed ID: 7567872.
    Abstract:
    The authors investigated markers of activation of CD25-, CD71- and HLD-DR molecules on CD3+, CD4+ and CD8+ lymphocytes simultaneously with cytochemical activity of the main energetic and synthetic enzymes in 34 patients with new-onset infiltrative tuberculosis of the lungs and in 30 healthy controls. It was found that reduced number of effector and regulatory lymphocyte subpopulations was recorded only in patients with advanced infiltrative tuberculosis in line with a sharp decline in enzymatic and functional activity of immunocompetent cells. In local infiltrative tuberculosis impairment of activation processes occurs only at intracellular level in time of energy metabolism shift to predominant glycolysis, this allowing lymphocytes to persist functionally active. A close relationship is shown between glycolytic enzymes and activation of CD3+ cells and their subpopulations. Basing on the above findings, one may refer the above enzymes to intracellular activation markers of lymphocytes.
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