These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The input-output relations of skeletal muscle.
    Author: Kwende MM, Jarvis JC, Salmons S.
    Journal: Proc Biol Sci; 1995 Aug 22; 261(1361):193-201. PubMed ID: 7568272.
    Abstract:
    We used three approaches to determine the stimulation patterns that maximize the isometric force-time integral per impulse (FTIpP) available from tibialis anterior muscles of the rabbit. Initially the interval between two pulses was fixed at the value that gave the maximum force-time integral, and successive pulses were added at intervals that maximized the FTIpP. We checked this iterative approach by a second method, in which a computer-generated protocol was used to deliver randomized bursts to the muscles. These experiments confirmed that optimal stimulation patterns for fast muscles consisted of an initial high-frequency portion followed by a train of impulses at a lower frequency. However, for muscles that had been stimulated chronically at a constant low frequency, an initial high-frequency portion conferred no advantage. In a third set of experiments we used constant-frequency bursts to generate contour surfaces that represented the dependence of FTIpP on the frequency and number of impulses. The results agreed with those from the earlier methods. We conclude that optimized patterns have potential for clinical use, but their value will depend strongly on the activation characteristics of the stimulated muscle.
    [Abstract] [Full Text] [Related] [New Search]