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  • Title: Temporary increase of plasma epinephrine affects stress responses 24 h later.
    Author: Porta S, Epple A, Kvetnansky R, Leitner G, Emsenhuber W, Radkohl W.
    Journal: Physiol Behav; 1995 Aug; 58(2):223-8. PubMed ID: 7568423.
    Abstract:
    The impact of temporary (24 h) implantation of epinephrine tables on catecholamine responses to handling and immobilization 24 h later was investigated in rats. Free plasma epinephrine responded with an increase to both types of stress (77% and 326%, respectively) while controls showed a weaker response to immobilization. The basal level of free plasma norepinephrine was reduced (46% vs. controls) after epinephrine pretreatment, but neither handling nor immobilization had a specific effect on this parameter. In contrast, the basal level of free plasma dopamine was increased after epinephrine pretreatment (183%); however, as with free norepinephrine, there was no specific effect of handling or immobilization. Conjugated plasma epinephrine was significantly lowered after epinephrine pretreatment (44% vs. controls). It did not respond specifically to handling or immobilization except for a stronger response after 20 min of immobilization. Conjugated norepinephrine showed no specific response, but increased nonspecifically after extended immobilization. Conjugated dopamine was lowered (30%-48%) in the E-treated group and did not respond to stress at any time. Thus, a temporary elevation of free plasma epinephrine affected, differentially, basal levels and stress responses of free and conjugated catecholamines 24 h later.
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