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  • Title: A controlled double-blind trial of moclobemide and imipramine in the treatment of depression.
    Author: Kok LP, Tsoi WF.
    Journal: Singapore Med J; 1995 Feb; 36(1):38-40. PubMed ID: 7570133.
    Abstract:
    The aim of this study is to compare the antidepressant efficacy and side effects of moclobemide with imipramine (a standard antidepressant). Moclobemide is a reversible inhibitor of monoamine-oxidase-A (RIMA) with selectivity for the MAO type A isoenzyme. Thirty-two patients who met DSM-3R criteria for major depressive episode or dysthymia were randomly assigned to receive either moclobemide or imipramine in a double-blind prospective study. The results indicated no difference in antidepressive efficacy between the two drugs, but imipramine had more anticholinergic side-effects. Neither drug had significant effects on pulse rate, blood pressure, weight changes or blood chemistry. These results were confirmed by previous studies.
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