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Title: Alveolar soft part sarcoma. Report of a case diagnosed by needle aspiration cytology and electron microscopy. Author: Husain M, Nguyen GK. Journal: Acta Cytol; 1995; 39(5):951-4. PubMed ID: 7571976. Abstract: BACKGROUND: Alveolar soft part sarcoma (ASPS) is a rare tumor, accounting for less than 1% of all primary soft tissue malignant neoplasms. The tumor is a distinct clinicopathologic entity, but its histogenesis is controversial. CASE: The needle aspirate from a soft tissue tumor in a 15-year-old girl was stained with Diff-Quik and periodic acid--Schiff (PAS) with and without prior digestion with diastase. Minute tumor tissue fragments were processed for transmission electron microscopic examination (EM). Clustered malignant cells with ill-defined, frothy or vacuolated cytoplasm showed a positive reaction with PAS and PAS with prior diastase digestion and oval nuclei containing macronucleoli. Intracytoplasmic, membrane-bound, rhomboid and rod-shaped crystals with a regular lattice pattern with 50-80 A periodicity were detected by EM study of aspirated tumor cells. CONCLUSION: Light and EM studies of aspirated tumor cells showed diagnostic features of the tumor.[Abstract] [Full Text] [Related] [New Search]