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  • Title: [Inhibitory effect of tocainide on calcium current and potassium current in guinea pig ventricular myocytes].
    Author: Wu BW, Sheng BT, Wang WZ, Zhao RR.
    Journal: Yao Xue Xue Bao; 1995; 30(6):412-6. PubMed ID: 7572180.
    Abstract:
    In whole cell voltage clamp experiment with isolated guinea pig ventricular myocytes, tocainide was shown to exhibit a concentration-dependent inhibition of calcium current (ICa) and delayed rectifier potassium current (IK). Tocainide with a therapeutic concentration of 50 mumol.L-1 significantly inhibited the ICa and Itail (deactivating tail current of IK) by 16% and 3% respectively. Inhibition of ICa by tocainide was also shown to be dependent upon stimulating frequencies, with a greater blockade occurring at 2.0 Hz (57%) than at 0.2 Hz (17%). Tocainide was found to inhibit the IK,ATP by 74% at 200 mumol.L-1 but not at 50 mumol.L-1. These inhibitory effects on ICa and IK can probably explain the therapeutic effect of tocainide on supraventricular tachycardia, and the shortening of plateau phase of action potential.
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