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  • Title: A correlation of the effects of normoxia, hyperoxia and anoxia on PO2 of endolymph and cochlear potentials.
    Author: Prazma J, Fischer ND, Biggers WP, Ascher D.
    Journal: Hear Res; 1978 Oct; 1(1):3-9. PubMed ID: 757230.
    Abstract:
    Change in PO2 in endolymph, endocochlear potentials and cochlear microphonics have been tested in normoxia, hyperoxia and anoxia on 24 guinea pigs. The polarographic method and construction of oxygen-sensitive microelectrodes is described in detail. The normal level of PO2 in endolymph vaires between 20 and 30 mm Hg. One-minute anoxia induced by breathing 100% N2 caused a decline in PO2, EP and CM, but during recovery only PO2 returned with over-correction to the preexposure level. Hyperoxia evoked by breathing 100% oxygen failed to increase the cochlear potentials and the PO2 in the endolymph. This suggests that vasoconstriction most likely occurs proximal to the capillaries bed of the stria vascularis.
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