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  • Title: Search for a gene predisposing to manic-depression on chromosome 21.
    Author: Byerley W, Holik J, Hoff M, Coon H.
    Journal: Am J Med Genet; 1995 Jun 19; 60(3):231-3. PubMed ID: 7573177.
    Abstract:
    Six kindreds containing multiple cases of Manic-depressive illness (MDI) were genotyped with seven highly polymorphic microsatellite loci used in the construction of an index map for chromosome 21. The kindreds were also genotyped with a microsatellite polymorphism for PFKL, a chromosome 21 locus that has shown suggestive linkage to MDI in one pedigree [Straub et al., 1993: The American Society of Human Genetics]. Evidence of linkage was not found assuming either autosomal dominant or recessive inheritance. The nonparametric affected sib pair test did not yield significant evidence of linkage.
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