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  • Title: Follicular Hodgkin's disease.
    Author: Ashton-Key M, Thorpe PA, Allen JP, Isaacson PG.
    Journal: Am J Surg Pathol; 1995 Nov; 19(11):1294-9. PubMed ID: 7573692.
    Abstract:
    We describe four cases of Hodgkin's disease that presented histologically as purely follicular lesions. The Reed-Sternberg (RS) cells were of classic and lacunar type and had the phenotype of usual Hodgkin's disease (CD30 and CD15 positive) but also expressed B-cell antigens (CD20 and CD79a). In each case the follicles consisted principally of mantle-zone B cells, which enclosed the RS cells; the follicle centres were atrophic, usually eccentrically placed, and did not contain RS cells. Fifteen cases of typical nodular sclerosing Hodgkin's disease were reviewed in parallel. B-cell antigen expression by RS cells was found in 10 cases (66%), and RS cells were present in follicular mantles in 10 cases. These findings suggest that some RS cells may be derived from B cells in the follicular mantle.
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