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  • Title: Alterations in the ultraviolet absorption spectra of steroids upon binding to serum proteins.
    Author: Stroupe SD, Westphal U.
    Journal: Biochemistry; 1978 Mar 07; 17(5):882-7. PubMed ID: 75741.
    Abstract:
    Difference spectra of progesterone-binding globulin (PBG) complexes with progesterone and testosterone were measured. The contributions of steroid and protein to the difference spectra were resolved by use of 5alpha-pregane-3,20-dione and dihydrotestosterone to compensate for the perturbation of PBG. The absorption spectra of seven bound steroids all showed increased extinction coefficients, sharpened absorption bands, a small blue shift, and an increased area implying an enhanced transition moment. This is in contrast to the steroid complexes with the low affinity binders, human serum albumin, and alpha 1-acid glycoprotein, which exhibit decreased extinction coefficients and reduced transition moments.
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